CORM-3

SKU: orb1300755

Description

CORM-3 is a ruthenium-based carbon monoxide-releasing molecule (CORM) developed for research. It is utilized in both in vitro and in vivo studies to investigate the therapeutic potential of CO, particularly in models of inflammation, cardiovascular ischemia-reperfusion injury, and organ protection.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 475473-26-8
• MW: 294.61
• Purity: 98.00% (May vary between batches)
• Formula: C₅H₄ClNO₅Ru
• SMILES: C(#O)[Ru+2]1(C#O)(C#O)([Cl-])[O-]C(=O)C[NH2]1
• Target: NOD-like Receptor (NLR),NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.2 mM);DMSO:50 mg/mL (169.72 mM)

Bioactivity

• In Vivo:
  CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model.
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• In Vitro:
  CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NOD-like Receptor, NOD-like Receptor (NLR), NODlike Receptor (NLR), NODlikeReceptor, NODlikeReceptor(NLR), Nuclear factor-κB, Nuclear factor-kappaB, NLR, NF-κB, NFκB, NF-kB, NFkB, Inhibitor, inhibit, CORM 3, CORM3, CORM-3

Quick Database Links

Gene Symbol

NOD-like Receptor (NLR),NF-κB