CORM-3

SKU: orb1224999

Description

CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

Key Properties

• CAS Number: 475473-26-8
• MW: 294.61
• Purity: >98% (HPLC)
• Formula: C₅H₄ClNO₅Ru
• SMILES: [*].Cl[Ru]1(NCC(=O)O1)(C=O)(C=O)C=O |$;_R0;;;;;;;;;;;;;$|
• Target: Others
• Solubility: DMSO:38 mg/mL (128.98 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice. Animal model: WT mice (C57BL/6J male, 8e10 weeks old). Dosage: 4 mg/kg. Administration: IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130. Result: Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge In vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged. Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged.
  Read more...
• In Vitro:
  CORM-3 suppresses caspase-1 activation and the secretion of interleukin (IL)-1β and IL-18 in macrophages in response to lipopolysaccharide (LPS) and ATP. CORM-3 inhibits the oligomerization of the adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which is required for NLRP3-dependent caspase-1 activation.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others