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Conteltinib

SKU: orb1707435

Description

Conteltinib (CT-707) is a multi-target kinase inhibitor active against FAK, ALK, and Pyk2. It demonstrates antitumor efficacy in research models of ALK-positive NSCLC and hepatocellular carcinoma, where it overcomes sorafenib resistance by inhibiting YAP signaling under hypoxic conditions.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1384860-29-0
MW635.82
Purity98.12% (May vary between batches)
FormulaC32H45N9O3S
SMILESCOc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
TargetPYK2,ALK,FAK
SolubilityDMSO:20 mg/mL (31.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.15 mM)

Bioactivity

Target IC50
FAK:1.6 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ALK, Conteltinib, CT 707, CT707, CT-707, FAK, SY-707, PYK2

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Key Properties

No computed properties available.

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Protocol Information

Conteltinib (orb1707435)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 270.00
10 mg
$ 280.00
25 mg
$ 460.00
50 mg
$ 620.00
100 mg
$ 850.00
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