1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

SKU: orb1305935

Description

SC-1 is a sorafenib-derived small molecule that potently inhibits STAT3 phosphorylation and activation, leading to apoptosis in hepatocellular carcinoma cells. It is used in cancer research, particularly for studying STAT3 signaling pathways in vitro.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1313019-65-6
• MW: 431.8
• Purity: 99.41% (May vary between batches)
• Formula: C₂₁H₁₃ClF₃N₃O₂
• SMILES: FC(F)(F)C1=CC(NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2)=CC=C1Cl
• Target: Apoptosis,STAT
• Solubility: DMSO:55 mg/mL (127.37 mM)

Bioactivity

• In Vivo:
  Compound SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo.
• In Vitro:
  Compound SC-1 (1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells. Compound SC-1 (1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.
• Animal Research:
  Compound SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cyclin-D1, Apoptosis, anticancer, 1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea, 1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea, kinase, Inhibitor, inhibit, orally, SHP-1, p-STAT3, survivin, STAT, STAT3

Compound Identifiers

PubChem CID

53327725