Coenzyme A

SKU: orb1309821

Description

Coenzyme A (CoA) is an essential cofactor synthesized from pantothenate, ATP, and cysteine, crucial for cellular metabolism. It is widely used in research on enzymatic assays, metabolic studies, and investigations into lipid biosynthesis and energy production in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 85-61-0
• MW: 767.53
• Purity: 93.84% (May vary between batches)
• Formula: C₂₁H₃₆N₇O₁₆P₃S
• SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OCC([C@H](C(NCCC(NCCS)=O)=O)O)(C)C)(=O)O)(=O)O)[C@H]1OP(=O)(O)O
• Target: Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.3 mM);DMSO:102 mg/mL (132.89 mM)

Bioactivity

• In Vitro:
  Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT. Many human pathologies, including cancer, diabetes, and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

metabolism, inhibit, Inhibitor, Human Endogenous Metabolite, fatty acid metabolism, EndogenousMetabolite, Endogenous Metabolite, acyl group carrier, citric acid cycle, Coenzyme A, ubiquitous essential cofactor

Compound Identifiers

PubChem CID

87642