Coenzyme A

SKU: orb1220002

Description

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT. Many human pathologies, including cancer, diabetes, and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.

Key Properties

• CAS Number: 85-61-0
• MW: 767.53
• Purity: >98% (HPLC)
• Formula: C₂₁H₃₆N₇O₁₆P₃S
• SMILES: CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCS
• Target: Endogenous Metabolite
• Solubility: In Vitro: H2O : 125 mg/mL (162.86 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Endogenous Metabolite