Clomiphene citrate

SKU: orb1224905

Description

A non-steroidal, a widely used fertility agent that inhibits estrogen receptor in the hypothalamus; shows antibacterial activity by inhibiting undecaprenyl diphosphate synthase, an enzyme that catalyzes the synthesis of a polyisoprenoid essential for both peptidoglycan and wall teichoic acid (WTA) synthesis.Other Indication Approved.

Key Properties

• CAS Number: 50-41-9
• MW: 598.0831
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₆ClNO₈
• SMILES: CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• Target: Estrogen Receptor/ERR
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: Female ICR mice. Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Resulted in a decrease in the number of ovulated oocytes and a significant increase in hyperploidy at 100 mg/kg. Animal model: letrozole(HY-14248)-induced PCOS rats. Dosage: 1 mg/kg. Administration: Oral. Result: Demonstrated a statistically raised NRF-2 gene expression. Up-regulated expression of NF-κB. Showed a reversal of the memory defect. Down-regulated of acetylcholine esterase expression.
• In Vitro:
  Cell Viability Assay Cell line: PC3 human prostate cancer cells. Concentration: 50 μM. Incubation time: 1 min, 2 min, 5 min, 10 min, 15 min, 20 min, 30 min. Result: Reduced cell viability by 10-50% for 2-15 min in a time-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clomifene citrate

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR