Enclomiphene citrate

SKU: orb1299929

Description

Enclomiphene citrate is the trans-isomer of clomiphene, functioning as a non-steroidal estrogen receptor antagonist. It is utilized in research to study hormonal regulation, with applications in both in vitro receptor binding assays and in vivo models of endocrine function.

Research Area

Metabolism Research

Key Properties

• CAS Number: 7599-79-3
• MW: 598.08
• Purity: 99.95% (May vary between batches)
• Formula: C₃₂H₃₆ClNO₈
• SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCOc1ccc(cc1)C(\c1ccccc1)=C(\Cl)c1ccccc1
• Target: Estrogen Receptor/ERR
• Solubility: DMSO: 250 mg/mL (418 mM)

Bioactivity

• In Vivo:
  total testosterone (TT) levels increased between baseline and after 16 weeks of treatment in all the treatment groups. FSH and LH levels increased in the enclomiphene citrate groups and decreased in the testosterone gel group at 16 weeks. Enclomiphene citrate maintained sperm concentration in the normal range over the treatment period, while there was a marked reduction in spermatogenesis in the testosterone gel group.
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• Animal Research:
  Two parallel randomised, double-blind, double-dummy, placebo-controlled, multicentre, phase III studies were undertaken to evaluate two doses of enclomiphene citrate vs testosterone gel on total testosterone (TT), LH, FSH, and sperm counts in overweight men aged 18-60 years with secondary hypogonadism. Men were screened and enrolled in the trials (ZA-304 and ZA-305). All enrolled men had early morning serum TT levels in the low or low normal range (≤300 ng/dL; ≤10.4 nmol/L) and had low or normal LH (<9.4 IU/L) levels measured on two separate occasions 2-10 days apart. Serum samples were obtained over the course of the study to determine relevant hormone levels at baseline and after 16 weeks of treatment. Men provided semen samples twice to enroll at the beginning and twice at the end of the study.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

trans-Clomiphene citrate, Enclomifene citrate, (E)-Clomiphene citrate

Compound Identifiers

PubChem CID

6420009