Clobetasol propionate

SKU: orb1308179

Description

Clobetasol propionate is a potent synthetic corticosteroid that activates glucocorticoid receptors to modulate gene expression, exerting anti-inflammatory effects by inhibiting phospholipase A2 and arachidonic acid release. It is widely used in research models of dermatological inflammation, including in vitro assays and in vivo studies of psoriasis and eczema.

Research Area

Metabolism Research

Key Properties

• CAS Number: 25122-46-7
• MW: 466.97
• Purity: 99.41% (May vary between batches)
• Formula: C₂₅H₃₂ClFO₅
• SMILES: CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl
• Target: Glucocorticoid Receptor,Cytochromes P450
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:86 mg/mL (184.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.07 mM);Ethanol:16 mg/mL (34.26 mM)

Bioactivity

• Target IC50:
  CYP3A5:0.206 μM (IC50)|CYP3A4:15.6 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cytochrome P450, CYPs, Dermovate, dermatoses, Clobetasol, Clobetasol 17-propionate, Clobetasol propionate, Clobetasol Propionate, corticosteroid, CGP9555, CGP-9555, CGP 9555, CCl 4725, Inhibitor, GlucocorticoidReceptor, Glucocorticoid Receptor, inhibit, psoriasis, Temovate

Compound Identifiers

PubChem CID

2791