Clioquinol

SKU: orb1310209

Description

Clioquinol is a lipophilic, copper-chelating 8-hydroxyquinoline derivative with oral bioavailability. It exhibits antifungal and antiparasitic properties and has been investigated in vitro and in vivo for its potential anticancer mechanisms.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130-26-7
• MW: 305.5
• Purity: 98.09% (May vary between batches)
• Formula: C₉H₅ClINO
• SMILES: OC1=C(I)C=C(Cl)C2=C1N=CC=C2
• Target: Autophagy,Parasite,Mitophagy,Antifungal,Antibiotic
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (8.18 mM);DMSO:55 mg/mL (180.03 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:1 mg/mL (3.27 mM)

Bioactivity

• Cell Research:
  DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl2 for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Antibiotic, Clioquinol, Chinoform, Fungal, Inhibitor, inhibit, Iodochlorhydroxyquin, Mitochondrial Autophagy, Mitophagy

Compound Identifiers

PubChem CID

2788