Clioquinol

SKU: orb1310209

Description

Clioquinol is a lipophilic, copper-chelating 8-hydroxyquinoline derivative with oral bioavailability. It exhibits antifungal and antiparasitic properties and has been investigated in vitro and in vivo for its potential anticancer mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 130-26-7
• MW: 305.5
• Purity: 98.09% (May vary between batches)
• Formula: C₉H₅ClINO
• SMILES: OC1=C(I)C=C(Cl)C2=C1N=CC=C2
• Target: Autophagy,Parasite,Mitophagy,Antifungal,Antibiotic
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (8.18 mM);DMSO:55 mg/mL (180.03 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:1 mg/mL (3.27 mM)

Bioactivity

• Cell Research:
  DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl2 for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Antibiotic, Clioquinol, Chinoform, Fungal, Inhibitor, inhibit, Iodochlorhydroxyquin, Mitochondrial Autophagy, Mitophagy

Compound Identifiers

PubChem CID

2788