Climbazole

SKU: orb1308725

Description

Climbazole (BAY-e 6975) is an imidazole-based antifungal compound used in anti-dandruff formulations. It is applied in dermatological research to study fungal infections, with utility in both in vitro assays and in vivo models for evaluating topical antifungal efficacy.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 38083-17-9
• MW: 292.76
• Purity: 98.23%
• Formula: C₁₅H₁₇ClN₂O₂
• SMILES: C(OC1=CC=C(Cl)C=C1)(C(C(C)(C)C)=O)N2C=CN=C2
• Target: Antifungal,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.83 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (170.79 mM);Ethanol:55 mg/mL (187.87 mM)

Bioactivity

• In Vivo:
  The MICs of Climbazole ranged from <0.06 to 1 μg/mL, with a median value of 0.06 μg/mL. Climbazole showed high in vitro and in vivo efficacy against Pityrosporum ovale, which may be a major cause of dandruff.
• In Vitro:
  The MICs of Climbazole ranged from <0.06 to 1 μg/mL, with a median value of 0.06 μg/mL. Climbazole showed high in vitro and in vivo efficacy against Pityrosporum ovale, which may be a major cause of dandruff.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, hepatic, exosome, Fungal, Climbazole, cytochrome, Antibiotic, antifungal, biogenesis, BAY-e 6975, secretion, P450

Compound Identifiers

PubChem CID

37907