Climbazole

SKU: orb1225151

Description

Climbazole is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits.(In Vitro):Climbazole (20 μM; 48 hours) significantly decreases exosome secretion in aggressive prostate cancer (PCa) cells.Climbazole (20 μM) significantly inhibits the protein concentration of Alix, and Rab27a but not nSMase2.Climbazole is a potent inhibitor of exosome biogenesis and/or secretion.

Key Properties

• CAS Number: 38083-17-9
• MW: 292.77
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₇ClN₂O₂
• SMILES: CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)C2=NC=CN2)=O
• Target: Others
• Solubility: Ethanol: 59 mg/mL (201.53 mM); DMSO: 59 mg/mL (201.53 mM)

Bioactivity

• In Vitro:
  Climbazole (20 μM; 48 hours) significantly decreases exosome secretion in aggressive prostate cancer (PCa) cells. Climbazole (20 μM) significantly inhibits the protein concentration of Alix, and Rab27a but not nSMase2.Climbazole is a potent inhibitor of exosome biogenesis and/or secretion.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Climbazole | Baypival | Climbazol | Baysan

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Gene Symbol

Others