CK1-IN-1

SKU: orb1301828

Description

CK1-IN-1 (PUN51207) is a potent and selective small molecule inhibitor of casein kinase 1, demonstrating IC50 values of 15 nM for CK1δ, 16 nM for CK1ε, and 73 nM for p38σ MAPK. This compound is a valuable research tool for studying CK1 signaling in circadian rhythms, Wnt/β-catenin pathways, and neurodegenerative disease models, both in vitro and in vivo.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1784751-20-7
• MW: 383.39
• Purity: 98.79%
• Formula: C₂₄H₁₅F₂N₃
• SMILES: Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1ccc2ccccc2c1F
• Target: p38 MAPK,Casein Kinase
• Solubility: DMSO:60 mg/mL (156.5 mM);H2O:Insoluble

Bioactivity

• Target IC50:
  CK1ε:16 nM (cell free)|p38σ MAPK:73 nM (cell free)|CK1δ:15 nM (cell free)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK1, CK1 IN 1, CK1IN1, CK-1-IN-1, CK1-IN-1, Casein Kinase, CaseinKinase, inhibit, Inhibitor, PUN 51207, PUN51207, PUN-51207, p38σ MAPK, p38MAPK, p38 MAPK

Compound Identifiers

PubChem CID

118303686