CK-869

SKU: orb1301424

Description

CK-869

Research Area

Signal Transduction

Key Properties

• CAS Number: 388592-44-7
• MW: 394.28
• Purity: 99.85%
• Formula: C₁₇H₁₆BrNO₃S
• SMILES: COc1ccc(N2C(SCC2=O)c2cccc(Br)c2)c(OC)c1
• Target: Arp2/3 Complex,Microtubule Associated
• Solubility: DMSO:75 mg/mL (190.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM)

Bioactivity

• Target IC50:
  ARP3:7 μM|ARP2:7 μM
• In Vitro:
  CK-869 inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM.It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
• Cell Research:
  Cells were treated in suspension with different concentrations of the compounds, allowed to adhere to the surface of a tissue culture dish for one hour, washed and the number of adherent cells counted and presented as a fraction of untreated cells (10X lens, 10 fields/condition). For cell spreading assays, cells were treated with CK-869 in suspension, plated on coverslips coated with 5 μg/ml fibronectin for imaging.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK 869, CK869, CK-869, Arp2/3 Complex, Actin-related protein 2/3 complex, MicrotubuleAssociated, Microtubule Associated, inhibit, Inhibitor

Compound Identifiers

PubChem CID

3574452