CIL-56

SKU: orb1225391

Description

YAP1 inhibitor CA3 (CA3;CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/Tead transcriptional activity; also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo; can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU; triggers nonapoptotic cell death, a potent and selective probe of ferroptosis; stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.

Key Properties

• CAS Number: 300802-28-2
• MW: 489.6
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₇N₃O₅S₂
• SMILES: O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(N4CCCCC4)=O)C=C3)/C2=N\O)(N5CCCCC5)=O
• Target: Ferroptosis
• Solubility: DMSO: 88 mg/mL (179.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YAP1 inhibitor CA3

Quick Database Links

Gene Symbol

Ferroptosis