CID755673

SKU: orb1305456

Description

CID755673

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 521937-07-5
• MW: 217.22
• Purity: 99.84%
• Formula: C₁₂H₁₁NO₃
• SMILES: Oc1ccc2oc3c(CCCNC3=O)c2c1
• Target: Serine/threonin kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.21 mM);DMSO:65 mg/mL (299.24 mM)

Bioactivity

• Target IC50:
  PKD2:280 nM|PKD3:227 nM|PKD:182 nM
• In Vivo:
  In HeLa cells, CID755673 significantly blocks the PMA-induced nuclear export of HDAC5 and also inhibits protein transport mediated by PKD. Furthermore, CID755673 directly inhibits the activity of PKD1 in LNCaP prostate cancer cells. This compound effectively prevents the migration and invasion of prostate cancer cells, as well as inhibiting tumor cell proliferation, and altering cell cycle distribution.
• In Vitro:
  In an acute pancreatitis model in rats, CID755673 significantly ameliorates the severity of necrosis and pancreatitis through its inhibitory action on PKD/PKD1.
• Cell Research:
  Cell proliferation was determined by counting the number of viable cells upon trypan blue staining. Cell proliferation is measured by CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CID 755673, CID755673, CID-755673, inhibit, Inhibitor, Protein kinase D, Serine kinase, threonin kinase, Serinekinase, threoninkinase, PKD, PKD2, PKD3, PKD1

Compound Identifiers

PubChem CID

755673