kb-NB142-70

SKU: orb1226716

Description

kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM; displays 10-fold increase in the in vitro PKD1 inhibitory potency versus CID755673; inhibits PC-3, PANC-1, CFPAC-1 cellular growth with IC50 of 5-30 uM.

Key Properties

• CAS Number: 1233533-04-4
• MW: 251.318
• Purity: >98% (HPLC)
• Formula: C₁₁H₉NO₂S₂
• SMILES: O=C1NCCSC2=C1SC3=CC=C(O)C=C32
• Target: PKD
• Solubility: DMSO: 25.13 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12, 13-dibutyrate (PDBu).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

kb NB 142-70 | kb NB142-70 | kb NB-142-70

Quick Database Links

Gene Symbol

PKD