CI-947

SKU: orb1223509

Description

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.

Key Properties

• CAS Number: 96392-15-3
• MW: 383.4012
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁N₅O₄
• SMILES: C1CC2=CC=CC=C2C1NC3=C4C(=NC=N3)N(C=N4)C5C(C(C(O5)CO)O)O
• Target: Adenosine Receptor
• Solubility: DMSO: ≥ 3.9 mg/mL

Bioactivity

• In Vivo:
  PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing. Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing. Animal model: 24 male beagle dogs (8-12 months old). Dosage: 2 mg/kg or 10 mg/kg. Administration: Oral administration; 16 hours and 24 hours. Result: Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD-117519 | PD 117519 | PD117519 | CI 947 | CI947

Quick Database Links

Gene Symbol

Adenosine Receptor