ChX710

SKU: orb1308846

Description

ChX710 is a small molecule activator of the cytosolic DNA-sensing pathway. It triggers the type I interferon response by promoting IRF3 phosphorylation and priming specific Interferon-Stimulated Genes (ISGs). This tool compound is valuable for studying antiviral immunity and autoimmune disorders in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2438721-44-7
• MW: 323.39
• Purity: 99.83% (May vary between batches)
• Formula: C₁₈H₂₁N₅O
• SMILES: CC(CN(C)C)NC(=O)c1cccc2nc([nH]c12)-c1ccncc1
• Target: STING
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.09 mM);DMSO:60 mg/mL (185.53 mM)

Bioactivity

• In Vitro:
  The treatment of ChX710 efficiently prime the cellular response to DNA transfection via STING as assessed by strong synergistic effects on IFN-β expression at both transcriptional and protein levels.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ChX 710, ChX710, ChX-710, Inhibitor, ERIS, MITA, MPYS, inhibit, TMEM173, Stimulator of Interferon Genes, STING

Compound Identifiers

PubChem CID

135397145