Chromium picolinate

SKU: orb1222683

Description

Chromium picolinate is used to prevent chromium deficiency and to decrease serum glucose and insuline levels. It also decreases plasma lipid levels and platelet aggregation and improves myocardial contractility.

Key Properties

• CAS Number: 14639-25-9
• MW: 418.3
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₂CrN₃O₆
• SMILES: [Cr+3].[O-]C(=O)c1ccccn1.[O-]C(=O)c1ccccn1.[O-]C(=O)c1ccccn1
• Target: p38|DNA mutation
• Solubility: In Vitro: DMSO : 7.81 mg/mL (18.67 mM)

Bioactivity

• In Vivo:
  Animal model: Goto-Kakizaki diabetic rats. Dosage: 100 mg/kg. Administration: p.o. Result: Increased body weight. The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats. Animal model: Streptozotocin-induced diabetic rats. Dosage: 1 mg/kg. Administration: p.o. Result: Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats. Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.
• In Vitro:
  Cell Viability Assay Cell line: lymphocytes. Concentration: 5, 10, 25, 50, 75, 100 μM. Incubation time: 24-72 h. Result: Inhibited cell viability from concentration of 25 μM. Western blot analysis. Cell line: lymphocytes. Concentration: 50, 100 μM. Incubation time: 24 h. Result: Increased the expression of Bax. and cytochrome. Increased the activity of caspase-3.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCRIS 8310 | CCRIS-8310 | Divista | Picolinic acid, chromium salt

Quick Database Links

Gene Symbol

p38|DNA mutation