Chlorin E6

SKU: orb2901023

Description

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.

Key Properties

• CAS Number: 19660-77-6
• MW: 596.67
• Purity: >98% (HPLC)
• Formula: C₃₄H₃₆N₄O₆
• SMILES: CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c(CC(O)=O)c4[nH]c(cc1n2)c(C)c4C(O)=O)c(C)c3C=C
• Target: Parasite
• Solubility: In Vitro: DMSO : 20.83 mg/mL (34.91 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Animal model: B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse. Dosage: 2.5 mg/kg. Administration: Intravenous injection (i. v.). Result: Significantly reduced tumor volume.
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• In Vitro:
  Western blot analysis. Cell line: AsPC-1 and MIA PaCa-2 Cells. Concentration: 5 μM, 10 μM. Incubation time: 3 h. Result: Significantly reduced Bcl-2 protein expression while increasing apoptotic molecule expression of Bax. Activated caspase-3 through its cleavage and upregulated the expression of cleaved PARP-1 in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Parasite