Chelidonic acid

SKU: orb1301694

Description

Chelidonic acid, a bioactive component of Chelidonium majus L., exhibits mild analgesic, antimicrobial, CNS sedative, and anti-inflammatory properties. It is used in research to investigate inflammation and neuropharmacology in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 99-32-1
• MW: 184.1031
• Purity: 99.03% (May vary between batches)
• Formula: C₇H₄O₆
• SMILES: OC(=O)C1=CC(=O)C=C(O1)C(O)=O
• Target: NF-κB,Caspase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.00 mg/mL (5.43 mM);DMSO:4.00 mg/mL (21.73 mM)

Bioactivity

• Target IC50:
  Glutamate decarboxylase (GAD):1.2 μM (Ki)
• In Vivo:
  Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reactions induced by ovalbumin in mice by inhibiting caspase-1 activity.
• Animal Research:
  female BALB/c mice was Maintained 6-week-old under pathogen-free conditions. Sensitized mice on days 1, 5, and 14 by intraperitoneal injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA. Chelidonic acid was administrated orally before intranasal . OVA challenge for 10 days. Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chelidonic acid, Caspase, Caspase-1, gamma-Pyrone-2,6-dicarboxylic acid, NF-κB, Nuclear factor-kappaB, Nuclear factor-κB, NFκB, NF-kB, NFkB, inhibit, Inhibitor, Jerva acid, Jervaic acid, r-Pyrone-2,6-dicarboxylic acid, γ-Pyrone-2,6-dicarboxylic acid

Compound Identifiers

PubChem CID

7431