Chelidonic acid

SKU: orb1220853

Description

Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.

Key Properties

• CAS Number: 99-32-1
• MW: 184.1
• Purity: >98% (HPLC)
• Formula: C₇H₄O₆
• SMILES: OC(=O)c1cc(=O)cc(o1)C(O)=O
• Target: Caspase
• Solubility: DMSO:4 mg/mL (21.72 mM)

Bioactivity

• In Vivo:
  Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.
• In Vitro:
  Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM. Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Jerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid

Quick Database Links

Gene Symbol

Caspase