CGP71683 hydrochloride

SKU: orb1301667

Description

CGP71683 hydrochloride is a potent and selective NPY Y5 receptor antagonist with a Ki of 1.3 nM, exhibiting significantly lower affinity for Y1 and Y2 receptors. This compound is a valuable research tool for investigating the role of the Y5 receptor in appetite regulation and energy homeostasis in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 192322-50-2
• MW: 512.07
• Purity: 99.92% (May vary between batches)
• Formula: C₂₆H₃₀ClN₅O₂S
• SMILES: Cl.Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
• Target: Neuropeptide Y Receptor
• Solubility: H2O:10 mg/mL (19.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.81 mM);DMSO:120 mg/mL (234.34 mM)

Bioactivity

• Target IC50:
  Y2 receptor:200 nM (Ki)|Y5 receptor:1.3 nM (Ki)|Y1 receptor:>4000 nM (Ki)
• In Vivo:
  CGP71683 (1-10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 71683, CGP 71683 Hydrochloride, CGP-71683, CGP71683, CGP71683 hydrochloride, CGP71683 Hydrochloride, CGP-71683 Hydrochloride, CGP-71683 hydrochloride, CGP71683A, Inhibitor, inhibit, NPY receptor, NeuropeptideYReceptor, neuropeptide Y (NPY) receptor, Neuropeptide Y Receptor, Y5 receptor

Compound Identifiers

PubChem CID

9849276