CGP71683 hydrochloride

SKU: orb1220901

Description

CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.

Key Properties

• CAS Number: 192322-50-2
• MW: 512.07
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₀ClN₅O₂S
• SMILES: Cl.Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
• Target: Neuropeptide Y Receptor
• Solubility: DMSO: 120 mg/mL (234.34 mM);Water: 10 mg/mL (19.53 mM)

Bioactivity

• In Vivo:
  CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.
• In Vitro:
  CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP71683A

Quick Database Links

Gene Symbol

Neuropeptide Y Receptor