Ceruletide

SKU: orb1308465

Description

Ceruletide is a synthetic decapeptide agonist of cholecystokinin receptors, inducing gallbladder and bile duct contraction. It is widely utilized in biomedical research to establish experimental models of pancreatitis and to study gastrointestinal physiology in both in vivo and in vitro settings.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 17650-98-5
• MW: 1352.4
• Purity: 99.54% (May vary between batches)
• Formula: C₅₈H₇₃N₁₃O₂₁S₂
• SMILES: CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
• Target: Cholecystokinin Receptor
• Solubility: DMSO:255 mg/mL (188.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (3.7 mM);H2O:5 mg/mL (3.7 mM)

Bioactivity

• Target IC50:
  mice:1012 mg/kg (LD50)
• In Vivo:
  Ceruletide (5-15 ng/kg intravenously) has a significant spasmodic effect on the pylorus in rats; Ceruletide (0.4-0.5 mcg/kg intravenously; 3-4 mcg/kg subcutaneously) causes vomiting and defecation in conscious dogs .
• In Vitro:
  Ceruletide is biologically and chemically identical to the human gastrointestinal hormones cholecystokinin-pancreatin (CCK) and gastrin II；Ceruletide stimulates gallbladder contraction while delaying gastric emptying and inhibiting motility of the proximal duodenum . Ceruletide activates NF-κB/Rel in vitro at high doses (but not physiological doses), which may induce a self-defense gene program before cell damage occurs and may protect pancreatic acinar cells from further damage after secretagogue overstimulation .

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, FI 6934, FI6934, FI-6934, CCK Receptor, Caerulein, Cholecystokinin receptor, Cholecystokinin, Cholecystokinin Receptor, Cerulein, Ceruletide

Compound Identifiers

PubChem CID

16129675