Ceruletide

SKU: orb1219588

Description

Ceruletide is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts.Ceruletide is same as biologically and chemically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction, while delaying gastric emptying and inhibiting motility in the proximal duodenum. Ceruletide in supramaximal but not in physiological doses activates NF-kappaB/Rel in vitro. This activation may induce a self-defending genetic program before the onset of cellular injury and may prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation.Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide SBA stimulation may perform as well as PP SBA stimulation in dogs with portosystemic shunt (PSS) and be more sensitive for the detection of hepatic dysfunction in dogs with upper respiratory disease (URD).

Key Properties

• CAS Number: 17650-98-5
• MW: 1352.41
• Purity: >98% (HPLC)
• Formula: C₅₈H₇₃N₁₃O₂₁S₂
• SMILES: NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc3cnc2ccccc23)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(OS(=O)(=O)O)cc4)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]5CCC(=O)N5)CCC(N)=O)[C@@H](C)O
• Target: Cholecystokinin Receptor
• Solubility: H2O:100 mg/mL (73.94 mM); DMSO:96 mg/mL (70.98 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caerulein,Cerulein,FI-6934

Quick Database Links

Gene Symbol

Cholecystokinin Receptor