CEP-28122

SKU: orb1701650

Description

CEP-28122 is a potent, selective, and orally bioavailable small molecule inhibitor of anaplastic lymphoma kinase (ALK). It is utilized in preclinical research to investigate ALK-driven pathologies, demonstrating efficacy in both cellular assays and animal models of ALK-positive cancers.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1022958-60-6
• MW: 539.07
• Purity: 99.87%
• Formula: C₂₈H₃₅ClN₆O₃
• SMILES: N([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C3=NC(NC=4C(OC)=C5C(=CC4)CC[C@@H](CC5)N6CCOCC6)=NC=C3Cl
• Target: ALK
• Solubility: DMSO:10 mM

Bioactivity

• Target IC50:
  ALK:1.9 ± 0.5 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CEP28122, CEP-28122, CEP 28122, Cluster of differentiation 246, CD246, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), ALK, ALK tyrosine kinase receptor, Inhibitor, inhibit

Compound Identifiers

PubChem CID

57325421