Cefotaxime

SKU: orb1940960

Description

Cefotaxime is an inhibitor of penicillin binding protein.(In Vitro):Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.(In Vivo):The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63527-52-6
• MW: 455.46
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇N₅O₇S₂
• SMILES: CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(N)n1
• Target: Antifection
• Solubility: DMSO:91 mg/mL (199.79 mM)

Bioactivity

• In Vivo:
  The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus In vivo than previously used regimens. Animal model: Female, specific pathogen free, 8-week-old BALB/c mice. Dosage: 30 mg/kg. Administration: IP every 6 h. Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
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• In Vitro:
  Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antifection