CDK6/PIM1-IN-1

SKU: orb1686970

Description

CDK6/PIM1-IN-1 is a potent dual inhibitor of CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM), also strongly inhibiting CDK4 (IC50: 3.6 nM). It demonstrates anti-AML activity by inhibiting cell proliferation, inducing G1 phase arrest, and promoting apoptosis in acute myeloid leukemia models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2677026-14-9
• MW: 473.55
• Formula: C₂₅H₂₈FN₉
• SMILES: N(CC)(CC)C1=NC2=C(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5CCNCC5)=NC=C3F)N=C1
• Target: Others,Pim,Apoptosis,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163196279