CDK6/PIM1-IN-1 hydrochloride

SKU: orb3135246

Description

CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual inhibitor of CDK6 and PIM1, with IC50 values of 39 nM and 88 nM, respectively. It also inhibits CDK4 with an IC50 of 3.6 nM. This compound significantly suppresses the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle at the G1 phase, and induces apoptosis. CDK6/PIM1-IN-1 hydrochloride demonstrates anti-AML activity.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2677026-15-0
• MW: 510.01
• Formula: C₂₅H₂₉ClFN₉
• SMILES: Cl.FC1=CN=C(N=C1C=2C=CC=3N=CC(=NC3C2)N(CC)CC)NC4=NC=C(C=C4)N5CCNCC5
• Target: Apoptosis,CDK,Pim

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,CDK,Pim