Cdk4 Inhibitor

SKU: orb2283806

Description

PD 0332991 is a cell-permeable, ATP-competitive inhibitor selectively targeting Cdk4/6 with high potency (IC50 = 76 nM). It induces G1 arrest by blocking Rb phosphorylation and demonstrates robust antiproliferative activity in vitro (e.g., HCT-116 cells) and in vivo tumor models, making it a key tool for cell cycle and oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 546102-60-7
• MW: 404.2
• Formula: C₂₀H₁₀BrN₃O₂
• SMILES: O=C1C2=C3C(=C4C(=C2C(=O)N1)C=5C(N4)=CC=CC5)NC=6C3=CC=C(Br)C6
• Target: Others,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

5330797