CDK2-IN-4

SKU: orb1308473

Description

CDK2-IN-4 is a highly selective CDK2 inhibitor, exhibiting potent activity against CDK2/cyclin A (IC50 = 44 nM) with over 2000-fold selectivity versus CDK1/cyclin B. This compound is a valuable chemical probe for studying cell cycle progression, proliferation, and oncology research in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2079895-42-2
• MW: 442.49
• Purity: 99.10% (May vary between batches)
• Formula: C₂₃H₁₈N₆O₂S
• SMILES: NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3[nH]cnc3n2)cc1
• Target: CDK
• Solubility: DMSO:19.83 mg/mL (44.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.52 mM)

Bioactivity

• Target IC50:
  CDK2-CyclinA:44 nM (IC50)|CDK1-CyclinB:86 μM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Cyclin dependent kinase, CDK2IN4, CDK-2-IN-4, CDK2-IN-4, cdk2/cyclinA, CDK2 IN 4, cdk2/cyclin A, Cdk1/cyclin B, Cdk1/cyclinB, CDK

Compound Identifiers

PubChem CID

123132899