CDDO-dhTFEA

SKU: orb1308849

Description

CDDO-dhTFEA is a synthetic oleanane triterpenoid that dually activates the Nrf2 antioxidant pathway and inhibits the NF-κB inflammatory pathway. It has demonstrated efficacy in preclinical CKD models, reducing fibrosis, inflammation, and improving hemodynamics, supporting its research use in oxidative stress and fibrotic diseases.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1191265-33-4
• MW: 574.72
• Purity: 99.59% (May vary between batches)
• Formula: C₃₃H₄₅F₃N₂O₃
• SMILES: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
• Target: Apoptosis,Nrf2,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.74 mM);DMSO:100 mg/mL (174 mM)

Bioactivity

• In Vivo:
  CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Nrf2, Keap1-Nrf2, inhibit, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, CDDOdhTFEA, CDDO-dhTFEA, CDDO dhTFEA, RTA dh 404, RTA dh404, RTA dh-404

Compound Identifiers

PubChem CID

66775163