CD73-IN-4

SKU: orb1218417

Description

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2216764-29-1
• MW: 463.81
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₃ClN₅O₇P
• SMILES: O[C@H]1[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@H](COCP(O)(O)=O)[C@H]1O
• Target: CD73
• Solubility: DMSO:125 mg/mL (265.19 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10 000 nM) against CD39, A2aR, and NTPDase2, 3, and 8.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CD73