CD38 inhibitor 1

SKU: orb1308474

Description

CD38 inhibitor 1 is a highly potent small molecule antagonist of both human (IC50 = 7.3 nM) and murine (IC50 = 1.9 nM) CD38. This tool compound is suitable for investigating CD38's role in immunology, cancer, and metabolic disorders across in vitro and in vivo research applications.

Research Area

Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1700637-55-3
• MW: 413.53
• Purity: 99.99% (May vary between batches)
• Formula: C₂₂H₂₇N₃O₃S
• SMILES: COCCO[C@H]1CC[C@@H](CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1
• Target: CD38
• Solubility: DMSO:66.25 mg/mL (160.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.84 mM)

Bioactivity

• Target IC50:
  CD38:1.9 nM(mouse)|CD38:7.3 nM(human)
• In Vivo:
  METHODS: CD38 inhibitor 1 (compound 78c) was administered intraperitoneally (10 (young mice), 15 (old mice) mg/kg, twice daily) for 4 to 14 weeks, and 78c concentrations in various tissues and plasma were measured. RESULTS Although CD38 inhibitor 1 promoted increases in NAD levels and exercise capacity in old mice, it had no significant effect on NAD levels or exercise tolerance in young (3-month-old) mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mouse CD38, inhibit, Inhibitor, hCD38, CD38, CD38 inhibitor 1, CD-38 inhibitor 1, WT hCD38

Compound Identifiers

PubChem CID

118736856