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CD38 inhibitor 1

SKU: orb1218652

Description

CD38 inhibitor 1 is an inhibitor of CD38. For hCD38 and mouse CD38, the IC50s are 7.3 nM and 1.9 nM.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1700637-55-3
MW413.53
Purity>98% (HPLC)
FormulaC22H27N3O3S
SMILESCN(c(ccc(-c1cncs1)c1)c1C(NC(CC1)CCC1OCCOC)=C1)C1=O
TargetCD38
SolubilityDMSO:35.71 mg/mL (86.35 mM; Need ultrasonic)

Bioactivity

In Vivo
CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle. Animal model: Diet induced obese (DIO) C57Bl6 mice. Dosage: 30 mg/kg. Administration: Orally once. Result: NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
5 mg
$ 210.00
10 mg
$ 350.00
25 mg
$ 670.00
50 mg
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100 mg
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