CD33 (C2) Antibody, Rabbit Polyclonal

SKU: orb67209

Description

Rabbit polyclonal to CD33.Myeloid cell surface antigen CD33 belongs to the immunoglobulin superfamily. It is a putativeadhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding tocells. It preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may bemasked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruitingcytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction throughdephosphorylation of signaling molecules. It induces apoptosis in acute myeloid leukemia.

Research Area

Immunology & Inflammation

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:1000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human CD33
• Molecular Weight: 40
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-CD33 antibody,anti-Myeloid cell surface antigen CD33 antibody,anti-Sialic acidbinding Iglike lectin 3 antibody,anti-Siglec3 antibody,anti-gp67 antibody,anti-SIGLEC3 antibody

Western blot of total cell extracts from human K562, using Ab (orb67209) at RT for 2 h.

Quick Database Links

UniProt

P20138