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CD105 Antibody / Endoglin
Catalog Number: orb639499
| Catalog Number | orb639499 |
|---|---|
| Category | Antibodies |
| Description | CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. CD105 has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | ENG/1326 |
| Tested applications | WB |
| Reactivity | Human |
| Isotype | Mouse IgG1, kappa |
| Immunogen | A partial recombinant protein corresponding to amino acids 74-251 of human CD105/Endoglin was used as the immunogen for the CD105 antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | Western blot: 1-2ug/ml |
| Purity | Protein G affinity chromatography |
| Conjugation | Unconjugated |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Hazard Information | This CD105 antibody is available for research use only. |
| UniProt ID | P17813 |
| Storage | Store the CD105 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
| Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
| Note | For research use only |
| Application notes | Titering of the CD105 antibody may be required for optimal performance. |
| Expiration Date | 12 months from date of receipt. |
Western blot testing of human 1) HeLa, 2) A431 and 3) HL60 cell lysate with CD105 antibody (clone ENG/1326). Observed molecular weight: 70/90 kDa (monomer, unmodified/glycosylated); 140-180 kDa (dimer, unmodified/glycosylated).
SDS-PAGE Analysis of Purified, BSA-Free CD105 Antibody (clone ENG/1326). Confirmation of Integrity and Purity of the Antibody.
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