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CD105 Antibody / Endoglin
Catalog Number: orb1822694
| Catalog Number | orb1822694 |
|---|---|
| Category | Antibodies |
| Description | CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG1, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A recombinant extracellular fragment of human Endoglin protein was used as the immunogen for the Endoglin antibody. |
| UniProt ID | P17813 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Antibody Type | Primary Antibody |
| Clone Number | ENG/4750 |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This Endoglin antibody is available for research use only. |
| Note | For research use only |
IHC staining of FFPE human placental tissue with Endoglin antibody (clone ENG/4750) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Endoglin antibody (clone ENG/4750) as confirmation of integrity and purity.
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