CCT007093

SKU: orb1225921

Description

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

Key Properties

• CAS Number: 176957-55-4
• MW: 272.39
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂OS₂
• SMILES: O=C1/C(CC/C1=C\C2=CC=CS2)=C/C3=CC=CS3
• Target: Phosphatase
• Solubility: DMSO: 1 mg/mL warmed (3.67 mM)

Bioactivity

• In Vivo:
  CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. Animal model: Wild-type mice. Dosage: 3.2 and 6.4 mg/kg. Administration: Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH). Result: Significantly improved survival in mice following major hepatectomy (80% hepatectomy). The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.
• In Vitro:
  CCT007093 (25 or 50 μM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line. CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells. CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition). Western blot analysis. Cell line: HEK293T cell line. Concentration: 25 or 50 μM. Incubation time: 8 h. Result: The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCT007093 | CCT-007093 | CCT 007093.

Quick Database Links

Gene Symbol

Phosphatase