CCBR1 Rabbit Polyclonal Antibody

SKU: orb100617

Description

CCBR1 Rabbit Polyclonal Antibody

Images & Validation

• Tested Applications: WB
• Dilution range: WB=1:500-1000
• Reactivity: Human
• Predicted Reactivity: Mouse, Rat

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: KLH conjugated synthetic peptide derived from human xCT/CCBR1
• Target: SLC7A11
• Molecular Weight: 55 kDa
• Purification: Affinity purified by Protein A
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: 0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
• Concentration: 1mg/ml
• Disclaimer: For research use only

Alternative Names

Amino acid transport system xc xCT antibody; Amino acid transport system xc-antibody Calcium channel blocker resistance protein CCBR1; Calcium channel blocker resistance protein CCBR1 antibody; CCBR1; Cysteine/glutamate transporter antibody; cystine/glutamate transporter; SLC7A11; Solute carrier family 7(anionic amino acid transporter light chain, xc-system), member 11; solute carrier family 7; Solute carrier family 7 member 11; Solute carrier family 7, (cationic amino acid transporter, y+system) member 11; xCT; XCT_HUMAN.

Sample: Lane 1: Human HepG2 cell lysates, Lane 2: Human HeLa cell lysates, Primary: Anti-CCBR1 (orb100617) at 1/1000 dilution, Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution, Predicted band size: 55 kDa, Observed band size: 57 kDa.

Quick Database Links

Gene Symbol

SLC7A11

UniProt

Q9UPY5

References

Marco Strecker 1, Keren Zohar 2, Martin Böttcher 3, Thomas Wartmann 2, Henry Freudenstein 1, Maximilian Doelling 1, Mihailo Andric 1, Wenjie Shi 1, Or Kakhlon 4 5, Katrin Hippe 6, Beatrix Jahnke 7, Dimitrios Mougiakakos 3, Franziska Baenke 7 8, Daniel Stange 7 8, Roland S Croner 1, Michal Linial 2, Ulf D Kahlert 1 9 Patient-specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity Mol Oncol, (2025)

PubMed: 40988536

Yulin Li et al. Mechanism of the enterobacterial metabolite sodium butyrate mediating ferroptosis to affect osteogenic ability of BMSCs in mice with estrogen deficiency-caused osteoporosis via the PTEN/PI3K/AKT pathway Apoptosis, (2025)

PubMed: 41205030

Applications

WB

Reactivity

Mouse

F Ye, Y Xu, X Zhu, Q Ding, Y Wang, S Lu, Y Chen The mechanism of E3 ubiquitin ligase HERC1 regulating ferroptosis in lung adenocarcinoma cells Cancer Genetics, (2025)

PubMed:

Applications

WB

Reactivity

Human

Li, Meng et al. Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K/AKT/mTOR Signaling Axis to Attenuate Steroid-Induced Osteoporosis Oxid Med Cell Longev, 2022, 8223737 (2022)

PubMed: 36035224

Applications

IHC

Reactivity

Rat