CBS1117

SKU: orb1298627

Description

CBS1117 is a potent small-molecule inhibitor of influenza A virus entry, exhibiting an IC50 of 70 nM against the A/Puerto Rico/8/34 (H1N1) strain. It functions by specifically disrupting hemagglutinin (HA)-mediated membrane fusion, making it a valuable tool for studying viral entry mechanisms in both cellular and animal infection models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 959245-08-0
• MW: 315.24
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₂₀Cl₂N₂O
• SMILES: CC(C)N1CCC(CC1)NC(=O)c1c(Cl)cccc1Cl
• Target: Influenza Virus
• Solubility: DMSO:13 mg/mL (41.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.34 mM)

Bioactivity

• Target IC50:
  H1N1:70 nM (IC50)
• In Vitro:
  CBS1117 which has a 50% inhibitory concentration of 70 nM and a selectivity index of ~4000 against A/Puerto Rico/8/34 (H1N1) infection in human lung epithelial cell line (A549).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBS 1117, CBS1117, CBS-1117, antiviral, A/Puerto Rico/8/34, A549, H1N1, entry, epithelial, lung, Influenza Virus, InfluenzaVirus, influenza A virus, influenza A, inhibit, Inhibitor

Compound Identifiers

PubChem CID

25236799