CBL (N) Antibody, Rabbit Polyclonal

SKU: orb67165

Description

Rabbit polyclonal to CBL.E3 ubiquitin-protein ligase CBL is an adapter protein that functions as a negative regulator of manysignaling pathways that are triggered by activation of cell surface receptors. It acts as an E3 ubiquitinproteinligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and thentransfers it to substrates promoting their degradation by the proteasome. CBL plays an important rolein the regulation of osteoblast differentiation and apoptosis and is essential for osteoclastic boneresorption. Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenilemyelomonocytic leukemia (NSLL).

Research Area

Cancer Biology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:2000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Human CBL protein 34-50aa
• Molecular Weight: Predicted molecular weight: 100 kDa, observed molecular weight: 120 kDa
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 1 x PBS (pH 7.4), 100 ug/ml rAlbumin, 40% Glycerol, 0.01% NaN3.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-CBL antibody, anti-E3 ubiquitinprotein ligase CBL antibody, anti-Casitas Blineage lymphoma protooncogene antibody, anti-Protooncogene cCbl antibody, anti- RING finger protein 55 antibody, anti-Signal transduction protein CBL antibody, anti-CBL2 antibody, anti-RNF55 antibody

Quick Database Links

UniProt

P22681