CB2R/FAAH modulator-2

SKU: orb1685597

Description

CB2R/FAAH modulator-2 (compound 26) is a dual-targeting small molecule acting as a cannabinoid CB2 receptor agonist (Ki = 10.8 nM) and a fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 6.2 μM). It is a research tool for investigating conditions such as cancer, neuroinflammation, and COVID-19, with utility in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2876918-68-0
• MW: 367.52
• Purity: 99.52% (May vary between batches)
• Formula: C₂₄H₃₃NO₂
• SMILES: N(C(=O)C1=C(OCC2CCCCC2)C=CC=C1)C34CC5CC(C3)CC(C4)C5
• Target: FAAH,Cannabinoid Receptor
• Solubility: DMSO:3.68 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  CB1:152.9 nM (Ki)|CB2:10.8 nM (Ki)
• In Vitro:
  CB2R/FAAH modulator-2 (compound 26) (10 μM) can reduce the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL-6 in unstimulated monocytes and macrophages .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CannabinoidReceptor, Cannabinoid Receptor, CB2R, CB2R/FAAH modulator2, CB2R/FAAH modulator-2, FAAH

Compound Identifiers

PubChem CID

168431271