β-catenin-IN-2

SKU: orb1297941

Description

β-catenin-IN-2 is a small molecule inhibitor targeting β-catenin, applicable for colorectal cancer research. It has been utilized in vitro to study Wnt/β-catenin signaling disruption and shows potential for in vivo efficacy studies in relevant cancer models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1458664-10-2
• MW: 255.29
• Purity: 99.93% (May vary between batches)
• Formula: C₁₅H₁₄FN₃
• SMILES: CN(C)c1ccc(cc1)-c1nc2ccc(F)cc2[nH]1
• Target: Wnt/beta-catenin
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (12.93 mM);DMSO:83.33 mg/mL (326.41 mM)

Bioactivity

• In Vitro:
  In HCT116 cells, β-catenin-IN-2 (10-40 μM) dose-dependently suppressed the transcriptional activity of the β-catenin/Tcf-4 .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, HCT116, HT-29, bcatenin, b-catenin-IN-2, cancer, cell, Colorectal, betacatenin, beta-catenin, beta-catenin-IN-2, Beta catenin, β catenin IN 2, βcatenin, βcateninIN2, β-catenin-IN-2, β-catenin, Tcf/4, Wnt, Wnt/b-catenin, Wnt/β-catenin, Wnt/betacatenin

Compound Identifiers

PubChem CID

60979451