Caspase,TNF,Akt,ATG,Apoptosis,Autophagy,JNK Antibody

SKU: orb3131575

Description

Zaptuzumab (AD5-10) is a humanized monoclonal antibody targeting death receptor 5 (DR5) with high selective binding affinity. It specifically induces cancer cell death through caspase-mediated apoptosis and autophagic cell death (ACD). Zaptuzumab can activate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Additionally, it induces reactive oxygen species (ROS) production and reduces glutathione (GSH) levels. In various xenograft mouse tumor models, Zaptuzumab has demonstrated significant tumor growth inhibition and favorable safety profiles.

Research Area

Cell Biology, Immunology & Inflammation; Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: Apoptosis,Caspase,Akt,TNF,ATG,Autophagy,JNK
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Akt,TNF,ATG,Autophagy,JNK