Carbonic anhydrase inhibitor 32

SKU: orb3027498

Description

Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 384.41
• Formula: C₁₇H₁₆N₆O₃S
• SMILES: O=C(C1=C(C)N(C2=CC=C(S(N)(=O)=O)C=C2)N=N1)N/N=C/C3=CC=CC=C3
• Target: mTOR,Carbonic Anhydrase,Na-K-Cl cotransporter

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

mTOR,Carbonic Anhydrase,Na-K-Cl cotransporter