Carbimazole

SKU: orb1225626

Description

Carbimazole is an imidazole antithyroid agent.

Key Properties

• CAS Number: 22232-54-8
• MW: 186.23
• Purity: >98% (HPLC)
• Formula: C₇H₁₀N₂O₂S
• SMILES: O=C(N1C=CN(C)C1=S)OCC
• Target: THR
• Solubility: Ethanol: 15 mg/mL (80.54 mM); DMSO: 38 mg/mL (204.04 mM)

Bioactivity

• In Vivo:
  Animal model: local breed adult healthy male rabbits. Dosage: 10, 15, 20 mg/animal/day. Administration: Oral gavage (p.o.) for 21 d. Result: Decreased rectal temperature, respiration rate, heart rate, the packed cell volume, Hb concentration and total leukocyte count, significantly decreased plasma glucose level; Increased serum levels of total protein, globulins while serum albumin level decreased; Lowered serum urea level while there was an increase in serum urea level with increase in dose level; Increased serum cholesterol level in a dose-dependent manner.
• In Vitro:
  Western blot analysis. Cell line: SK-N-SH. Concentration: 0.01-2 mM Incubation time: 6 h. Result: Induced the phosphorylation of eEF2 at Thr56 in a dose- and time-dependent manner through the phosphorylation of AMPK, resulting in a global translational inhibition.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Carbimazole | Neo-Tireol | Neomercazole | Thyrostat | Tyrazol |

Quick Database Links

Gene Symbol

THR