Carbenicillin disodium

SKU: orb1309624

Description

Carbenicillin disodium is a semi-synthetic, beta-lactamase-resistant penicillin with broad-spectrum bactericidal activity. It is widely used in molecular biology and microbiology research, including for in vitro selection of genetically engineered bacteria and in vivo studies involving susceptible bacterial infections.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4800-94-6
• MW: 422.36
• Purity: 85.18% (May vary between batches)
• Formula: C₁₇H₁₆N₂Na₂O₆S
• SMILES: [Na+].[C@H]1(C(=O)N2[C@@H]1SC([C@@H]2C(=O)[O-])(C)C)NC(=O)C(C(=O)[O-])c1ccccc1.[Na+]
• Target: Antibacterial,Antibiotic,Cell wall
• Solubility: H2O:9 mg/mL (21.31 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:62.5 mg/mL (147.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.74 mM)

Bioactivity

• In Vivo:
  Carbenicillin (125 mg/L) effectively suppresses the proliferation of soil bacteria, increases the volume of somatic embryos, and the number of somatic embryos per callus tissue. Within the callus tissue, Carbenicillin at concentrations of 250 mg/L to 500 mg/L can enhance the fresh weight of the tissue. At a higher concentration of 1 g/L, Carbenicillin reduces the germination frequency of leaf disc explants. Additionally, in vitro exposure of patients' isolated leukocytes to Carbenicillin (0.1 g/ml) does not result in histamine release.
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• In Vitro:
  In patients with cystic fibrosis, Carbenicillin (0.1μg/mL) exhibited no hypersensitivity drug reactions as measured by antibody levels. In chrysanthemums and TOBC, Carbenicillin (50 μg/mL) induced phytotoxicity in a concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Carbenicillin, Carbenicillin disodium, Bacterial, Antibiotic, Cellwall, Cell wall, cell wall, BRL2064, BRL-2064, BRL 2064, inhibit, Inhibitor, Sodium carbenicillin

Compound Identifiers

PubChem CID

20933